Efforts from diverse disciplines, including evolutionary studies and biomechanical experiments, have yielded new insights into the genetic, signaling, and mechanical control of tooth formation and functions. Evidence from fossils and non‐model organisms has revealed that a common set of genes underlie tooth‐forming potential of epithelia, and changes in signaling environments subsequently result in specialized dentitions, maintenance of dental stem cells, and other phenotypic adaptations. In addition to chemical signaling, tissue forces generated through epithelial contraction, differential growth, and skeletal constraints act (...) in parallel to shape the tooth throughout development. Here recent advances in understanding dental development from these studies are reviewed and important gaps that can be filled through continued application of evolutionary and biomechanical approaches are discussed. (shrink)

Infinitism is an ancient view in epistemology about the structure of knowledge and epistemic justification, according to which there are no foundational reasons for belief. The view has never been popular, and is often associated with skepticism, but after languishing for centuries it has recently begun a resurgence. Ad Infinitum presents new work on the topic by leading epistemologists. They shed new light on infinitism's distinctive strengths and weaknesses, and address questions, new and old, about its account of justification, reasoning, (...) epistemic responsibility, disagreement, and trust, among other important issues. The volume clarifies the relationship between infinitism and other epistemological views, such as skepticism, coherentism, foundationalism and contextualism, and it offers novel perspectives on the metaphysics, epistemology, and ethics of regresses and reasons. (shrink)

Interoception can be broadly defined as the sense of signals originating within the body. As such, interoception is critical for our sense of embodiment, motivation, and well-being. And yet, despite its importance, interoception remains poorly understood within modern science. This paper reviews interdisciplinary perspectives on interoception, with the goal of presenting a unified perspective from diverse fields such as neuroscience, clinical practice, and contemplative studies. It is hoped that this integrative effort will advance our understanding of how interoception determines well-being, (...) and identify the central challenges to such understanding. To this end, we introduce an expanded taxonomy of interoceptive processes, arguing that many of these processes can be understood through an emerging predictive coding model for mind–body integration. The model, which describes the tension between expected and felt body sensation, parallels contemplative theories, and implicates interoception in a variety of affective and psychosomatic disorders. We conclude that maladaptive construal of bodily sensations may lie at the heart of many contemporary maladies, and that contemplative practices may attenuate these interpretative biases, restoring a person’s sense of presence and agency in the world. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:PrefaceMost of the papers in this special issue of Diacritics were presented at a conference on the future of French studies organized at Cornell University with a special grant from the Office of the President, Hunter Rawlings III. The charge to the speakers was less to reflect on the situation of French studies in the American academy than to offer possibilities for the future, whether through programmatic argument or (...) illustration of the sort of work that might be undertaken under the banner of French studies. The editors have substituted for two papers from the conference that were already committed elsewhere two new papers from colleagues engaged in French studies at Cornell.The ongoing arguments about the future of French studies seem riven by a conflict of motives and aims. There are those who wish to confirm the dissolution of any fetishized notion of Frenchness, insisting on the multiplicity of francophonies and the fragmenting effects of globalization on anything that claims to be a specifically French identity. Conversely, there are those who promote French studies precisely as the defense of an irreducible specificity of things French, which is threatened by changes in the university and in the world and which the new field of French studies might have a chance of preserving. If these are not the options that our contributors embrace, it is not because they are insensible of their attractions—or of the beguiling possibility of combining them, by defining that essential Frenchness, to be pursued or preserved, as the dissolution of the idea of an essential Frenchness.One of the general aims of these papers is to promote and illustrate possibilities for novel kinds of reading and writing and for inventive modes of interdisciplinary study, which make French studies a lively field for students and teachers. But if there is a single substantial theme that runs through them all, it may be the mundane concern that Tom Conley calls “wondering what can be done to invigorate one of the richest of all literary canons.” How does that canon respond to the kinds of questions and issues that the unraveling and dissolution of boundaries—including those of France itself—have made possible? And should French studies, in the end, be conceived as the integration of the numerous interdisciplinary trajectories that depart from or traverse this canon or as a more distinctively specific practice for the study of everything French that is structured like a language?Copyright © 1999 The Johns Hopkins University Press... (shrink)

In this article, we explore how deep brain stimulation (DBS) devices designed to “close the loop”—to automatically adjust stimulation levels based on computational algorithms—may risk taking the individual agent “out of the loop” of control in areas where (at least apparent) conscious control is a hallmark of our agency. This is of particular concern in the area of psychiatric disorders, where closed-loop DBS is attracting increasing attention as a therapy. Using a relational model of identity and agency, we consider whether (...) DBS designed for psychiatric regulation may require special attention to agency. To do this, we draw on philosophical work on relational identity and agency, connecting it with reports from people using first-generation DBS devices for depression and obsessive-compulsive disorder. We suggest a way to extend a notion of relational agency to encompass neural devices. (shrink)

This volume presents new work on infinitism, the view that there are no foundational reasons for beliefs--an ancient view in epistemology, now growing again in popularity. Leading epistemologists illuminate its strengths and weaknesses, and address questions new and old about justification, reasoning, responsibility, disagreement, and trust.

This essay offers seven intersectional feminist principles for equitable and actionable COVID-19 data, drawing from the authors' prior work on data feminism. Our book, Data Feminism, offers seven principles which suggest possible points of entry for challenging and changing power imbalances in data science. In this essay, we offer seven sets of examples, one inspired by each of our principles, for both identifying existing power imbalances with respect to the impact of the novel coronavirus and its response, and for beginning (...) the work of change. (shrink)

There are many things that could be wrong with foundationalism. For example, some have claimed that a so‐called basic belief cannot be both 1) a reason for non‐basic beliefs and 2) such that it cannot be provided with at least prima facie justification.1 If something is a reason, they say, then that something has to be a proposition (or sufficiently proposition‐like) and if it is a proposition (or sufficiently proposition‐like), then it is the kind of thing that requires a reason (...) in order to be even prima facie justified.2 Another reason that some give for rejecting normative foundationalism is that it leads directly to skepticism.3 There is no way, they claim, to move from so‐called basic propositions (typically given as first person introspective reports) to “external world” propositions by employing normatively acceptable principles of reasoning.4 Still others have thought that the invention of a nonrea‐soned reason was as ad hoc as the invention of an unmoved mover.5. (shrink)

As the Pyrrhonians made clear, reasons that adequately justify beliefs can have only three possible structures: foundationalism, coherentism, and infinitism. Infinitism—the view that adequate reasons for our beliefs are infinite and non-repeating—has never been developed carefully, much less advocated. In this paper, I will argue that only infinitism can satisfy two intuitively plausible constraints on good reasoning: the avoidance of circular reasoning and the avoidance of arbitrariness. Further, I will argue that infinitism requires serious, but salutary, revisions in our evaluation (...) of the power of reasoning. Thus, reasoning can not provide a basis for assenting to a proposition—where to assent to a proposition, p, means to believe that we know that p. A non-dogmatic form of provisional justification will be sketched. Finally, the best objections to infinitism, including those posed by the Pyrrhonians, will be shown (at least provisionally!) to be inadequate. (shrink)

“Real knowledge,” as I use the term, is the most highly prized form of true belief sought by an epistemic agent. This paper argues that defeasible infinitism provides a good way to characterize real knowledge and it shows how real knowledge can arise from fallible justification. Then, I argue that there are two ways of interpreting Ernest Sosa's account of real knowledge as belief that is aptly formed and capable of being fully defended. On the one hand, if beliefs are (...) aptly formed only if they have a specific causal etiology, namely that they are efficiently caused fully or partially by virtuous characteristics of the epistemic agent, then Sosa's account falls prey to what I call the problem of the Hazard of Empirical Disconfirmation. The HED problem applies to all forms of causal accounts of real knowledge and is simply that as we gain more empirical knowledge about the causal origins of our true beliefs that are the most highly prized we will discover that they do not always satisfy the required efficient causal constraints. Bluntly put, having sufficiently good reasons for our beliefs might not require that the beliefs have the requisite efficient causal etiology. On the other hand, there is a way of interpreting Sosa's views that does not include an efficient causal prerequisite. That interpretation makes Sosa's account of real knowledge almost identical to defeasible infinitism but expressed in an alternate vocabulary. Such a view is not subject to the HED problem and it can solve the deep problem in epistemology, namely how to get epistemically certain knowledge from fallible justification. (shrink)

This chapter provides grounds for thinking that it is the quality of the reasons for the propositional content of our belief-states with true propositional contents, rather than the etiology of those belief-states, that determines whether the belief-state qualifies as knowledge. Normative epistemology rather than naturalized epistemology holds the key to understanding knowledge. This chapter delineates some important features of epistemic luck. It explores the etiology view and presents reasons for concluding that it cannot adequately account for epistemic luck. The chapter (...) then explores the reasons view and shows how it can account for some of the cases that are troublesome for the etiology view. There are many well-discussed and widely accepted counterexamples in the literature for each of the etiology views, with the exception of the virtue-views because those views are still relatively new. (shrink)

We demonstrate that an unlexicalized PCFG can parse much more accurately than previously shown, by making use of simple, linguistically motivated state splits, which break down false independence assumptions latent in a vanilla treebank grammar. Indeed, its performance of 86.36% (LP/LR F1) is better than that of early lexicalized PCFG models, and surprisingly close to the current state-of-theart. This result has potential uses beyond establishing a strong lower bound on the maximum possible accuracy of unlexicalized models: an unlexicalized PCFG is (...) much more compact, easier to replicate, and easier to interpret than more complex lexical models, and the parsing algorithms are simpler, more widely understood, of lower asymptotic complexity, and easier to optimize. (shrink)

Molecular genetic testing has increasingly been incorporated into clinical medicine, and this trend is likely to accelerate in the future. The introduction of genetic testing into medical practice is beginning to collide head on with patents that claim ownership of correlations between human genetic variants and predisposition to disease, response to therapeutic drugs, and susceptibility to pharmacologic side effects. Patent holders or licensees of genes, genetic variants, and their genotype-phenotype correlations are already using the threat of litigation to monopolize genetic (...) tests for important well-known syndromes like Duchenne Muscular Dystrophy and inherited breast and ovarian cancer, in addition to a host of less commonly discussed conditions. (shrink)

ABSTRACTNegative feedback has paradoxical features to it. This form of feedback can have informational value under some circumstances, but it can also threaten the ego, potentially upsetting behaviour as a result. To investigate possible consequences of the latter type, two experiments presented positive or negative feedback within a sequence-prediction task that could not be solved. Following feedback, participants had to control their behaviours as effectively as possible in a motor control task. Relative to positive feedback, negative feedback undermined control in (...) a manner suggesting emotional upset. These reactions lasted for at least three seconds and were especially pronounced among people reporting that they typically lose control in the context of their negative emotions. The findings document a novel form of behavioural dysregulation that occurs in response to negative feedback while also highlighting the utility of motor control perspectives on self... (shrink)

As the Pyrrhonians made clear, reasons that adequately justify beliefs can have only three possible structures: foundationalism, coherentism, and infinitism. Infinitism—the view that adequate reasons for our beliefs are infinite and non-repeating—has never been developed carefully, much less advocated. In this paper, I will argue that only infinitism can satisfy two intuitively plausible constraints on good reasoning: the avoidance of circular reasoning and the avoidance of arbitrariness. Further, I will argue that infinitism requires serious, but salutary, revisions in our evaluation (...) of the power of reasoning. Thus, reasoning can not provide a basis for assenting to a proposition—where to assent to a proposition, p, means to believe that we know that p. A non-dogmatic form of provisional justification will be sketched. Finally, the best objections to infinitism, including those posed by the Pyrrhonians, will be shown (at least provisionally!) to be inadequate. (shrink)